Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-09-06
1998-07-07
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
935 57, 935 71, 935 32, 536 23, 536 72, 435325, 435363, 435366, 435367, 435368, 435369, 435370, 435371, 4353711, 4353712, 4353713, 4352351, 424 931, 424 932, 424 9321, 514 44, C12N 510, C12N 508, C12N 522
Patent
active
057767432
ABSTRACT:
The present invention is directed to methods of sensitizing a human tumor cell with adenovirus E1A. The methods involve treating a human tumor cell by, first, introducing into the tumor cell nucleic acid encoding a polypeptide having adenovirus E1A activity, expressing the E1A active polypeptide in the cell, and then either contacting the E1A expressing tumor cell with a chemotherapeutic agent or irradiating the E1A-expressing tumor cell. The invention also provides methods of enhancing a subject's response to chemotherapy or irradiation by introducing into a subject's tumor cells nucleic acid encoding a polypeptide having adenovirus E1A activity, expressing the E1A active polypeptide in the cells and finally, administering either a chemotherapeutic agent or irradiation. The invention also provides a method of treating cancer.
REFERENCES:
patent: 5516631 (1996-05-01), Frisch
Orkin et al, "Report and Recomendations . . . Gene Therapy,"Dec. 7,1995 pp. 1-40. NIH.
Blaese M. et al. Cancer Gene Therapy 2(4): 291-297 (1995).
Culver, K.W. et al. "Gene Therapy for Cancer", Trends in Genetics 10(5). May 1994, pp. 174-178.
Brown, D. The Washington Post. Dec. 8, 1995. pp. A1, A22.
Marshall, E. Science 269: 1050-1055 (1995).
Yu et al., "Adenovirus type E1A gene products act as transformation suppressors of the neu oncogene." Molec. Cell. Biol.11:1745-1750 (1991).
Miller et al., "Improved retroviral vectors for gene transfer and expression."Biotechniques7:980-990 (1989).
Yu et al., "Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A."Cancer Research53:5784-5790 (1993).
Fujiwara et al., "Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene."Cancer Research54:2287-2291 (1994).
Matsuzaki et al., "Mechanism of selective killing by dilinoleoylglycerol of cells transformed by the E1A gene of adenovirus type 12."Cancer Research49:5702-5707 (1989).
Cook et al., "E1A oncogene expression level in sarcoma cells : an indepedent determinant of cytolytic susceptibility and tumor rejection."Oncogene8:625-635 (1993).
Cook et al., "Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells."Proc. Natl. Acad. Sci USA83:6965-6969 (1986).
Cook et al., "Adenovirus E1A gene induction of susceptibility to lysis by natural killer cells and activated macrophages in infected rodent cells."J. of Virology61(11):3510-3520 (1987).
Cook et al., "Differential induction of cytolytic susceptibility by E1A, myc, and ras oncogenes in immortalized cells."63(8) :3408-3415 (1989).
Cook et al., "Role of tumor necrosis factor-.alpha.in E1A oncogene-induced susceptibility of neoplastic cells to lysis by natural killer cells and activated macrophages."J. of Immunology 142 4527-4534 (1989).
Duerksen-Hughes et al., "Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor. "J. of Immunology143:4193-4200 (1989).
Walker et al., "E1A oncogene induction of cytolytic susceptibility eliminates sarcoma cell tumorigenicity."Proc. Natl. Acad. Sci. USA88:6491-6495 (1991).
Frisch Steven M., "Antioncogenic effect of adenovirus E1A in human tumor cells."Proc. Natl. Acad. Sci. USA,88:9077-9081 (1991).
Frisch and Francis, "Disruption of epithelial cell-matrix interactions induces apoptosis."J. Cell. Biol.,124(4):619-626 (1994).
Lowe et al., "p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents."Cell, 74:957-967 (1993).
Rao et al., "The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins."Proc.Natl. Acad. Sci. USA,89:7742-7746 (1992).
Evan et al., "Induction of apoptosis in fibroblasts by c-myc protein."Cell,69:119-128 (1992).
Chen et al., "Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF."Nature,330:581-583 (1987).
Fanidi et al., "Cooperative interaction between c-myc and bcl-2 proto-oncogenes."Nature,359:554-556 (1992).
Sanchez-Prieto et al., "Modulation of cellular chemoresistance in keratinocytes by activation of different oncogenes."Int. J. Cancer,60:235-243 (1995).
Gruber and Greil, "Apoptosis and therapy of malignant diseases of the hematopoietic system."Int. Arch. Allergy Immunol.,105:368-373 (1994).
Sinkovics and Horvath, "Apoptosis by Genetic Engineering."Leukemia,8:S98-S102 (1994).
Canman and Kastan, "Induction of apoptosis by tumor suppressor genes and oncogenes."Cancer Biol.,6:17-25 (1995).
Martin and Green, "Apoptosis as a goal of cancer therapy."Current Opinion in Oncology, 6:616-621 (1994).
La Jolla Cancer Research Foundation
Low Christopher S. F.
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