C-reactive proteins in treatment of animal and human cancers

Details C-reactive proteins in treatment of animal and human cancers C-reactive proteins in treatment of animal and human cancers

1986-07-18

1989-08-15

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, 514 21, 514885, 514886, 530351, A61K 3702

Patent

active

048573140

ABSTRACT:
A pharmaceutical composition comprising an effective antitumor amount of a protein having tumor necrosis activity such as human tumor necrosis factor and an effective immune system stimulating amount of C-Reactive Protein to enhance the antitumor activity of the tumor necrosis factor and a method for treating tumors which comprises administering to a subject having a tumor an effective antitumor amount of a protein having tumor necrosis activity and an effective amount of C-Reactive Protein to stimulate the immune system of the subject thereby enhancing the antitumor activity of the protein.

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Gewurz et al., Advances in Internal Medicine, vol. 27, 345-372 (1982).
Kaplan et al., The Journal of Immunology, vol. 112, No. 6, 2135-2147 (1974).
Todd et al., Nature, vol. 313, 803-806 (1985).

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