Substituted methanols

Details Substituted methanols Substituted methanols

1976-04-30

1978-05-16

Helfin, Bernard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260613R, 424341, 568808, 568807, 568812, 568813, C07C 4320

Patent

active

040899080

ABSTRACT:
The compounds are 1-aryl-1-alknyl-1-(t-butyl)-substituted methanols, e.g. 3-(2'-naphthyl)-4,4-dimethyl-pent-1-yn-3-ol, are useful as hypolipidemic agents, and are prepared by reacting a 4-aryl-pivalophenone with a metallo-alkynyl reagent under Grignard reaction conditions.

REFERENCES:
patent: 3929902 (1975-12-01), Galantay
patent: 3969415 (1976-07-01), Galantay
Cadiot, Ann. Chim. (Paris) Series 13, vol. 1, (1956) 214-229.
Papa et al., J.A.C.S., vol. 76 (1954), 4446-4450.

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