Process for the preparation of 21-hydroxy-16-pregnen-20-one deri

Details Process for the preparation of 21-hydroxy-16-pregnen-20-one deri Process for the preparation of 21-hydroxy-16-pregnen-20-one deri

1976-05-04

1978-05-16

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955C, 26023955D, 26039747, 2603975, 26039745, C07J 1700

Patent

active

040898520

ABSTRACT:
.DELTA..sup.16 -21-HYDROXY-20-KETO STEROIDS OF THE PREGNANE SERIES HAVING AN OTHERWISE UNSUBSTITUTED D-ring and a 13-methyl or -ethyl group, and 21-ethers and -esters thereof, are produced by reaction of a corresponding D-ring saturated 17-keto steroid with a lithium compound of the formula ##STR1## thereby converting the 17-keto group to a 17.beta.-hydroxy-20.alpha.-enol ether in which the 17.alpha.-side chain has the formula ##STR2## wherein R.sub.3 and R.sub.4 have the values given above, and, in any desired sequence, splitting off R.sub.3 and/or R.sub.4 enol ether by hydrolysis; eliminating 17.beta.-hydroxy group, preferably after acylation, with formation of a .DELTA..sup.16 -double bond; and, if desired, splitting off any blocking group.

REFERENCES:
patent: 3793350 (1974-02-01), Crabbe

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