Process for the preparation of liposomes

Details Process for the preparation of liposomes Process for the preparation of liposomes

1976-01-12

1978-05-16

Lovering, Richard D.

Compositions

Preservative agents

Anti-corrosion

424 36, 424 94, 424179, 424244, 424319, B01J 1302

Patent

active

040898016

ABSTRACT:
Synthetic liposomes, for example containing a biologically active substance, are prepared by dispersing a first aqueous liquid with the aid of ultrasonic vibration in a water-immiscible carrier liquid less dense than water in the presence of a compound of the formula XY where X is a hydrophilic polar group and Y is a hydrophobic non-polar group to form dispersed globules of the first aqueous liquid each bounded by a monomolecular layer of the compound XY; adding this dispersion to a second aqueous liquid to form a two layer system separated and bounded by a monomolecular second layer of the compound XY and then centrifuging the system to force the dispersed globules through the second boundary layer of the compound XY and into the second aqueous liquid.

REFERENCES:
patent: 3336155 (1967-08-01), Rowe
Papahadjopoulos et al.: "Cellular Uptake Of Cyclic AMP Captured Within Phospholipid Vesicles and Effect On Cell--Growth Behaviour", Biochim. Biophys. Acta, 363:404-418, (1974).
Papahadjopoulos et al.: "Cochleate Lipid Cylinders:Formation By Fusion of Unilamellar Lipid Vesicles", Biochim. Biophys. Acta, 394:483-491, (1975).

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