Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular v

Details Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular v Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular v

1988-03-25

1989-04-25

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544309, 544310, A61K 31495, C07D23924

Patent

active

048248517

ABSTRACT:
New pyrimidine derivatives of the formula: ##STR1## wherein Z is a group selected from ##STR2## in which R.sup.1 and R.sup.2 are each hydrogen, alkenyl, ar(lower)alkyl or lower alkyl optionally substituted with epoxy, hydroxy, amino and/or lower alkylamino and R.sup.5 is lower alkyl,

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patent: 4612376 (1986-09-01), Takaya et al.
patent: 4746664 (1988-05-01), Takaya et al.
Taguchi et al, CA91-211365q an J. Org. Chem. 1979, 44(24), 4385-4393.
Taguchi et al, CA88-5875r and J. Org. Chem. 1977, 42(25), 4127-4131.
Maehr et al, CA78-147903r and J. Heterocyclic Chem. 1972, 9(6), 1389-13 94.
Ekpenyong et al, CA89-197441m and Tetrahedron Lett. 1978(19), 1619-1622.

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