Substituted amide inhibitors of cholesterol absorption

Details Substituted amide inhibitors of cholesterol absorption Substituted amide inhibitors of cholesterol absorption

1987-06-25

1989-04-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514364, 514374, 514508, 514 88, 548136, 548236, 548237, 558 6, A61K 3142, A61K 31535, C07D26314, C07D26508

Patent

active

048248436

ABSTRACT:
Novel N-(substituted-phenyl)-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.

REFERENCES:
patent: 4413011 (1983-11-01), Sircar
patent: 4465507 (1984-08-01), Konno
patent: 4554282 (1985-11-01), Sircar
Kritchevsky, D. et al., Lipids, vol. 12, pp. 16-21 (1977).
Heider, J. G. et al., Journal of Lipid Research, vol. 24, pp. 1127-1134 (1983).
Clark, S. B. and Tercyak, A. M., Journal of Lipid Research, vol. 25, pp. 148-159 (1984).

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