Isoquinolinedione derivatives, pharmaceutical compositions and m

Details Isoquinolinedione derivatives, pharmaceutical compositions and m Isoquinolinedione derivatives, pharmaceutical compositions and m

1987-04-24

1989-04-25

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514309, 546 18, 546142, A61K 3147, C07D21724, C07D40112

Patent

active

048248355

ABSTRACT:
The present invention provides isoquinolinedione derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical which is optionally interrupted by a heteroatom or by a heteroatom substituted with an alkyl radical, R.sub.2 is a hydrogen atom or an alkyl or alkenyl radical, or together with R.sub.1, represents a cycloalkylene, alkylidene or cycloalkylidene radical which is optionally interrupted by a heteroatom or by a heteroatom substituted by an alkyl radical and R.sub.3 is a radical of the general formula: ##STR2## which can be in the 5- 6-, 7- or 8-position of the isoquinoline-1,3-dione and in which R.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms or alkyl, trihaloalkyl, cycloalkyl, cycloalkenyl, dealkylaminoalkyl, alkoxycarbonylalkyl, alkylcarbonyl, aryl or heterayl radicals and X is an oxygen or sulphur atom or a radical of the general formula .dbd.N--R.sub.6, in which R.sub.6 is a hydrogen atom, a cyano group of an alkyl radical; and the physiologically acceptable salts thereof.
The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. These new compounds have a blood pressure lowering effect and/or influence thrombocyte aggregation, improve the microcirculation, and exert a positive intropic effect, thus having therapeutic and prophylactic effects.

REFERENCES:
patent: 3406175 (1968-10-01), Lesher
patent: 4021558 (1977-05-01), Kutter et al.

Affiliated with

Also associated with

Rating

Isoquinolinedione derivatives, pharmaceutical compositions and m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isoquinolinedione derivatives, pharmaceutical compositions and m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoquinolinedione derivatives, pharmaceutical compositions and m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1195915