Spiro-imide derivatives

Details Spiro-imide derivatives Spiro-imide derivatives

1983-12-22

1984-09-11

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D491107, C07D49120, C07D49510, C07D49520

Patent

active

044711247

ABSTRACT:
A series of spiro-imide compounds and their base salts with pharmacologically acceptable cations are disclosed. These particular compounds are useful in therapy as agents for the control of certain chronic diabetic complications. Preferred member compounds include 2,3-dihydro-spiro-[1H-indene-1,3'-pyrrolidone]-2', 5'-dione, 2,3-dihydro-spiro-[1H-indene-2,3'-pyrrolidine]-2',5'-dione, 3,4-dihydro-spiro-[2H-naphthalene-1,3'-pyrrolidine]-2',5'-dione, 3,4-dihydro-spiro-[2H-naphthalene-1,3'-piperidine]-2', 6'-dione, 6-chloro-2,3-dihydro-spiro-[4H-1-benzopyran-4,3'-pyrrolidine]-2',5'-dione and 6,7-dihydro-spiro-[5H-benzo(b)thiophene-4,3'-pyrrolidine]-2',5'-dione. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 3507881 (1970-04-01), Sandberg
patent: 3821383 (1974-06-01), Sestanj et al.
Rice et al., Chem. Abs. 74, 125384 (1971).
J. Faust et al., in the Journal of the American Pharmaceutical Association, vol. XLVI, No. 2, p. 118 (1957).

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