Chemistry: molecular biology and microbiology – Vector – per se
Patent
1987-01-20
1988-10-18
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Vector, per se
435 68, 435 70, 435 91, 4351723, 435253, 435255, 435256, 935 22, 935 23, 935 27, 935 28, 935 29, 935 38, 935 41, 935 56, 935 69, 424 89, C12N 1500, C12N 100
Patent
active
047787619
ABSTRACT:
A recombinant plasmid inserted with Hepatitis B virus gene, which comprises a plasmid vector containing a yeast gene and an E. coli gene and carrying the expression control region of the repressible acid phosphatase gene of yeast and a Hepatitis B virus gene recombined thereto under control of the phosphatase promoter, a transformed yeast which is prepared by transforming a yeast with the recombinant plasmid, and a method of the production of Hepatitis B virus surface antigen in a large scale by culturing the transformed yeast in a medium. The Hepatitis B virus surface antigen prepared by the present invention has the same immunological properties as those of the natural antigen from human blood plasma and is useful for the preparation of Hepatitis B virus vaccine and diagnostic reagents.
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Hamada Fukusaburo
Matsubara Kenichi
Miyanohara Atsushi
Nozaki Chikateru
Ohtomo Nobuya
Juridical Foundation the Chemosero-Therapeutic Research Institut
Moskowitz Margaret
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