Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid deriv

Details Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid deriv Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid deriv

1982-12-21

1984-09-11

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546121, A61K 3144, C07D47104

Patent

active

044709862

ABSTRACT:
Disclosed are e.g. 5-(tetrazolylalkyl, hydroxycarbamoylalkyl)imidazo[1,5-a]-pyridines, and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.

REFERENCES:
patent: 3790586 (1974-02-01), Irikura et al.
patent: 4226878 (1980-10-01), Iizuka et al.
patent: 4256757 (1981-03-01), Hayashi et al.
patent: 4444775 (1984-04-01), Ford
P. Blatcher, et al., Tetrahedron Letters 21, 2195 (1980).
G. J. Durant, et al., J. Medicinal Chemistry 16, 1272 (1973).
W. W. Paudler, et al., J. Heterocyclic Chemistry 3, 33 (1966).
O. Fuentes, et al., J. Org. Chemistry 40, 1210 (1975).

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