Renin inhibitory peptides having His.sup.13

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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2601125R, C07C10352, A61K 3702

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active

044709714

ABSTRACT:
Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.

REFERENCES:
Powers et al., Acid Proteases, Structure, Function and Biology, Plenum Press 1977, 141-157.
Trends in Biochem. Sci, 1, 205-208, (1976).
Suketa et al., Biochemistry 14: 3188, 1975.
Swales, Pharmac. Ther. 7: 173-201, 1979.
Kokuba et al., Nature 217: 456-457, Feb. 3, 1968.
Matsushita et al., J. Antibiotics 28: 1016-1018, Dec. 1975.
Lazar et al., Biochem. Pharma. 23: 2776-2778, 1974.
Miller et al., Biochem. Pharma. 21: 2941-2944, 1972.
Haber, Clinical Science 59: 7s-19s, 1980.
Rich et al., J. Org. Chem. 43: 3624, 1978.
J. Med. Chem. 23: 27, 1980.
Umezawa et al., J. Antibiot. (Tokyo), 23: 259-262, 1970.
Gross et al., Science 175:656, 1971.
Tewksbury et al., Circulation 59, 60, Supp. II: 132, Oct. 1979.
Poulsen et al., Biochem. Biophys. Acta 452:533-537, 1976.
Skeggs, Jr. et al., J. Exp. Med. 106:439-453, 1957.
Kokubu et al., Biochem. Pharmacol. 22: 3217-3223, 1973.
Burton et al., Biochemistry 14: 3892-3898, 1975.
Poulsen et al., Biochemistry 12: 3877-3882, 1973.
Haber and Burton, Fed. Proc. Fed. Am. Soc. Exp. Biol. 38: 2768-2773, 1979.
Marshall, Federation Proc. 35: 2494-2501, 1976.
Burton et al., Proc. Natl. Acad. Sci. USA 77: 5476-5479, Sep. 1980.

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