Method of isolating radioactive perrhenate or pertechnetate from

Details Method of isolating radioactive perrhenate or pertechnetate from Method of isolating radioactive perrhenate or pertechnetate from

1985-11-27

1988-10-18

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

423 49, 534 10, 534 14, A61K 4300, C01G 4700, C01G 5700

Patent

active

047786728

ABSTRACT:
Pure perihenate is isolated from a aqueous crude solution of perrhenate by first associating the perrherate with a lipophilic counter ion such as tetrabutyl ammonium. This is added to the solution in a form such as tetrabutyl ammonium bromide. Tetrabutyl ammonium perrhenate is formed. The aqueous mixture is then added to a reverse phase separation column such as a C.sub.18 Sep Pak filter which has been previously loaded with the lipophilic counter ion. The aqueous portion of the crude mixture is eluted from the column with water. Subsequently the purified perrhenate associated with the lipophilic counter ion is removed with a less polar solvent such as ethanol. Pertechnetate can also be separated from an aqueous mixture in the same manner. These procedures are particularly suited for isolating relatively pure radioactive forms of perrhenate and pertechnetate such as Re.sup.186 O.sub.4.sup.-, Re.sup.188 O.sub.4.sup.-, and .sup.99m TcO.sub.4.sup.-.

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H. Feess et al., "Performance of Two Phase Electrolyte Electrolysis" in: N. L. Weinberger et al., Ed., Techniques in Chemistry, vol. V, part III, pp. 108-109.

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