Process for the preparation of alpha-alkylated alpha-amino acids

Details Process for the preparation of alpha-alkylated alpha-amino acids Process for the preparation of alpha-alkylated alpha-amino acids

1991-01-30

1992-10-06

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

544 89, 544137, 544 64, 544224, 544238, 544335, 544336, 544399, 546139, 546152, 546176, 546335, 548152, 548203, 548214, 548217, 548228, 5483097, 5483751, 5483391, 548 4CM, 5483491, 5483001, 5483794, 5483561, 558299, 558426, 560155, 560 24, 562443, 562503, 562505, 562506, 562553, 562574, 562575, C07D26308

Patent

active

051533588

ABSTRACT:
A novel process for the preparation of .alpha.-alkylated .alpha.-amino acids and .alpha.-halogenated .alpha.-amino acids is disclosed. These .alpha.-alkylated .alpha.-amino acids and .alpha.-halogenated .alpha.-amino acids are useful as intermediates for the preparation of enzyme inhibitors (for example, renin inhibitors) and other peptides or amino acid derivatives or analogs.

REFERENCES:
patent: 3715404 (1973-04-01), Kuch et al.
patent: 4264771 (1981-04-01), Steglich et al.
patent: 4371706 (1983-01-01), Edmonds et al.
patent: 4508921 (1985-04-01), Amato et al.
patent: 4535167 (1985-08-01), Freidinger
patent: 4992421 (1991-02-01), De

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