Spiro-tricyclicaromatic succinimide derivatives as inhibitors of

Details Spiro-tricyclicaromatic succinimide derivatives as inhibitors of Spiro-tricyclicaromatic succinimide derivatives as inhibitors of

1991-08-27

1992-10-06

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514376, 514409, 514866, 548147, 548216, 548411, A61K 3142, A61K 31425, C07D26352, C07D27760

Patent

active

051532115

ABSTRACT:
Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2',5-diones.

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