Method of inhibiting the activity of human immuno deficiency vir

Details Method of inhibiting the activity of human immuno deficiency vir Method of inhibiting the activity of human immuno deficiency vir

1991-04-25

1992-10-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3147

Patent

active

051532026

ABSTRACT:
A method for inhibiting the activity of human immunodeficiency virus (HIV) in vivo comprises administering to a human host an antimalarial drug, which is capable of exhibiting a protective effect, a curative effect, or of preventing transmission of malaria in humans. The antimalarial drug is pyrimaquine and is administered to the human in an amount sufficient to prevent or at least inhibit infection of T lymphocytes by HIV in vivo or to prevent or at least inhibit replication of HIV in vivo.

REFERENCES:
patent: 3005755 (1961-10-01), Schoen
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Medical Hypotheses, vol. 27, No. 2, Oct. 1988, pp. 147-148, Longman Group UK Ltd; J. P. Shoemaker: "Treatment for AIDS and Other Retrovirus-Caused Diseases".
Annals of Internal Medicine, vol. 106, No. 5, May 1987, pp. 714-718, American College of Physicians, US; R. D. Pearson et al.: "Use of Pyrimethamine-Sulfadoxine (Fansidar) in Prophylaxis Against Chloroquine-Resistant Plasmodium Falciparum and Pneumocystis Carinii".
Postgraduage Medical Journal, vol. 63, No. 740, Jun. 1987, pp. 509-510; R. Sandyk et al.: "Clomiphene Citrate in Tourette's Syndrome".
Chemical Abstracts, vol. 68, issued 1968, Columbus, Ohio USA Manolova et al., "Testing of the Antivival Properties of Some Compounds Acting on Influenza Virsus by the Immunofluorescence Method", see p. 4553, col. 2, the abstract No. 47143t, Kongr. Bulg. Mikrobiol. 1st Sofia 1967, 739-43 (Bulg).

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