Treatment of hypertension with angiotensin II blocking imidazole

Details Treatment of hypertension with angiotensin II blocking imidazole Treatment of hypertension with angiotensin II blocking imidazole

1989-11-13

1992-10-06

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 94, 514252, 514359, 514381, 514382, 514383, 514384, 514396, 514397, 514398, 514399, 514400, 548112, 548252, 548253, 548254, A61K 3141, A61K 31495, C07D25704, C07F 928

Patent

active

051531976

ABSTRACT:
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.

REFERENCES:
patent: 3772315 (1973-11-01), Regel et al.
patent: 4207324 (1980-06-01), Matsumura et al.
patent: 4226878 (1980-10-01), Iizuka et al.
patent: 4301169 (1981-11-01), Yamanaka et al.
patent: 4328349 (1982-05-01), Grayboyes et al.
patent: 4340598 (1982-07-01), Furukawa et al.
patent: 4347364 (1982-08-01), Walser et al.
patent: 4347365 (1982-08-01), Walser et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4379927 (1983-04-01), Vorbruggen et al.
patent: 4402966 (1983-09-01), Yamanaka et al.
patent: 4435395 (1984-03-01), Loev et al.
patent: 4448781 (1984-05-01), Cross et al.
patent: 4463011 (1984-07-01), Ogata
patent: 4532331 (1985-07-01), Frazee et al.
patent: 4533669 (1985-08-01), Yamanaka et al.
patent: 4539322 (1985-09-01), Campbell et al.
patent: 4602031 (1986-07-01), Yamanaka et al.
patent: 4689182 (1987-08-01), Rafferty
patent: 4755518 (1988-07-01), Rafferty
Carini et al., Chem. Abstracts, vol. 109, No. 15, 129008g (1988).
H. Torii, Takeda Kenkyusshoho, 40, No. 3/4, 180-191 (1982).
Pals et al., Circulation Research, 29, 673 (1971).
Streeten and Anderson, Handbook of Hypertension, vol. 5, Clinical Pharmogy of Antihypertensive Drugs, A. E. Doyle (Editor), Elsevier Science Publishers B.V., p. 246 (1984).
Satoh et al., Cir. Res., 36/37 & Suppl. I: I-89, 1975.
Chiu et al., "Non-Peptide Angiotensin II Receptor Antagonists, II, Pharmacology of S-8308," European Journal of Pharmacology, vol. 157, pp. 13-21 (1988).
Wong et al., Abstract No. 30, Hypertension, p. 340, vol. 12, No. 3, Sep. 1988, High Blood Pressure Council Mtg., San Francisco, CA, Sep. 28-Oct. 1, 1988, "X-6803 Methyl-2-N-Butyl-1-(4-(2-Carboxybenzamido)Benzyl-4-Chloroimidazole-5-Aceta te, Sodium Salt): A Novel Nonpeptide Angiotensin II Receptor Antagonist".
Chiu et al., Abstract No. 118.11, The Pharmacologist, vol. 30, p. A165, 1988, for ASPET Mtg., Montreal, Canada, Oct. 9-13, 1988, "Nonpeptide Angiotensin II (AII) Receptor Antagonists: Structure Function Studies".
Wong et al., Nonpeptide Angiotensin II Receptor Antagonists. I Pharmacological Characterization of 2-n-Butyl-Chloro-1(2-chlorobenzyl)imidazole-5-acetic Acid, Sodium Salt (S-8307), "J. Pharmacology and Experimental Therapeutics," vol. 247, No. 1, pp. 1-7 (1988).
Lindgren et al., Eur. J. Pharmacol. 135: 383, 1987.
Schmidt et al., J. Cardiovascular Pharmacology, vol. 8, pp. S100-105, 1986.

Affiliated with

Also associated with

Rating

Treatment of hypertension with angiotensin II blocking imidazole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of hypertension with angiotensin II blocking imidazole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of hypertension with angiotensin II blocking imidazole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1189300