Polysaccharide antigens

Details Polysaccharide antigens Polysaccharide antigens

1982-07-19

1984-09-11

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 11, 424 87, 424 92, C08B 3700

Patent

active

RE0316725

ABSTRACT:
Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11.times.10.sup.5 d. By employing a broth free from constituents having a molecular size above 10.sup.5, the antigens can be separated from the broth in high yield after harvesting the organisms. Vaccination of humans with Streptococcus agalactiae polysaccharide antigens having molecular sizes above 5.times.10.sup.5 produces in selected individuals specific antibody levels above 200 .mu.g/ml of antisera; globulins fractionated from such antisera contain most of the antibody and can be used for passive immunization.

REFERENCES:
patent: 3301848 (1967-01-01), Halleck
patent: 3856775 (1974-12-01), Fukuoka et al.
Baker et al., "Jour. of Experimental Medicine", vol. 143, 1976, pp. 258-269.
Baker et al., "Infection and Immunity", vol. 13, 1976, pp. 189-194.

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