Process and nitroaminopyrimidone intermediates for histamine H.s

Details Process and nitroaminopyrimidone intermediates for histamine H.s Process and nitroaminopyrimidone intermediates for histamine H.s

1980-05-19

1985-06-11

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544238, 544295, 544296, 544321, C07D

Patent

active

045230153

ABSTRACT:
A process for making substituted 2-aminopyrimidones which are histamine H.sub.2 -antagonists which comprises reacting a 2-nitroaminopyrimidone with a heteroarylalkylamine, heteroarylalkylthioalkylamine, or heteroarylalkoxyalkylamine. One particular compound which can be made by this process is 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-[5-(1,3-benzodioxyolyl )methyl]-4-pyrimidone. Also claimed are 2-nitroaminopyrimidone intermediates for use in this process. One specific intermediate is 2-nitroamino-5-[5-(1,3-benzodioxyolyl)methyl]-4-pyrimidone.

REFERENCES:
patent: 3932644 (1976-01-01), Durant et al.
patent: 4145546 (1979-03-01), Brown et al.
patent: 4154834 (1979-05-01), Brown et al.
patent: 4216318 (1980-08-01), Brown et al.
patent: 4227000 (1980-10-01), Brown
patent: 4305945 (1981-12-01), Canellin et al.

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