Process for making 2-amino-4-hydroxyquinolines

Details Process for making 2-amino-4-hydroxyquinolines Process for making 2-amino-4-hydroxyquinolines

1979-03-14

1981-01-27

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424258, 546 90, 546110, 2604655R, 260465E, 2603403, 2603405R, 544252, 544246, 544247, C07D21556, C07D22104

Patent

active

042476992

ABSTRACT:
The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxy-quinolines and 2-amino-.alpha.,.alpha.-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxy-quinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxy-pyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.

REFERENCES:
patent: 3647802 (1979-03-01), Carney
patent: 4058532 (1977-11-01), Bell
Coppola et al., "J. Org. Chem.", vol. 41, 1976, pp. 825-831.

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