Pharmacological dissolution method and apparatus

Details Pharmacological dissolution method and apparatus Pharmacological dissolution method and apparatus

1986-06-23

1989-08-15

Hornsby, Harvey C.

Agitating

By movement of support for removable mixing chamber

366142, 366213, 366234, 366349, 73866, 422277, B01F 100

Patent

active

048569097

ABSTRACT:
Standardized tests of the dissolution rates of pharmacologic dosage units such as salicylic acid tablets, for example, are conducted by placing the dosage unit in a liquid-permeable cylindrical wire basket and rotating the basket in the solvent about two different axes, preferably one vertical axis and one horizontal axis. The apparatus comprises an outer vertical tube to which the basket is mounted off center from the vertical axis of the tube so that it orbits around the vertical axis when the vertical outer tube is rotated; the basket is mounted on a horizontal shaft which can rotate about its horizontal axis. An inner shaft extends vertically through the outer vertical shaft, and bevel gears are provided between the horizontal shaft and the inner vertical shaft so that relative rotation of the upper ends of the inner and outer vertical shafts with respect to each other about their axes causes the basket to rotate about the horizontal shaft axis. By holding the inner shaft stationary and rotating the outer shaft, the desired two-axis motion of the basket is produced.

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"Variation on the USP-NF Rotating Basket Dissolution Apparatus and a New Device for Dissolution Rate Studies of Solid Dosage Forms"; Author: Haringer et al; Source: Journal of Pharmaceutical Sciences; Date: Jan. 1973; pp. 130-132.

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