Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-02
1996-12-24
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514313, 546157, 546159, 546162, 546112, 546287, 546288, 546289, 546296, 546297, 546307, 546309, 546310, A61K 3147, C07D21538, C07D21522, C07D21520
Patent
active
055873871
ABSTRACT:
The present invention is concerned with antiretroviral (e.g. anti-HIV-1)compounds having the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are halo or methyl; R.sup.3 is hydrogen, halo, nitro or trifiuoromethyl; R.sup.4 is trifiuoromethyl or methylcarbonyl; or a radical --C(.dbd.X)--NR.sup.5 R.sup.6 wherein X is O or S, and R.sup.5 and R.sup.6 each independently are hydrogen or C.sub.1-4 alkyl; or a radical -Alk-R.sup.7, wherein Alk is C.sub.1-4 alkanediyl; and R.sup.7 is hydrogen or hydroxy; Het is a heterocyclic radical of formula: ##STR2## Pharmaceutical compositions containing said compounds of formula (I) and processes of preparing said compounds and compositions.
REFERENCES:
patent: 4246429 (1981-01-01), Janssen et al.
patent: 5480997 (1996-01-01), Janssen et al.
Bosmans Jean-Paul R. M. A.
Janssen Marcel A. C.
Janssen Paul A. J.
Van Daele Georges H. P.
Verdonck Marc G. C.
Janssen Pharmaceutica N.V.
Metz Charles J.
Rotman Alan L.
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