Methylphosphonate dimer synthesis

Details Methylphosphonate dimer synthesis Methylphosphonate dimer synthesis

1994-12-09

1998-08-04

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2533, 536 2534, 536 265, 536 267, 536 268, C07H 2100

Patent

active

057895767

ABSTRACT:
Processes for the stereospecific synthesis of 2',2"-bis(deoxy)di-nucleosides and for the stereoselective synthesis of 2',2"-bis(substituted) dinucleosides are provided. Also provided are activated 2'-substituted-nucleoside alkylphosphonate active esters useful in the synthesis of these dinucleosides.

REFERENCES:
patent: 5166330 (1992-11-01), Engels et al.
Lesnikowski et al., Nucleic Acid Research, vol. 16, No. 24, pp. 11675-11689 (1988).

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