Subsurface thermal gradient spectrometry

Details Subsurface thermal gradient spectrometry Subsurface thermal gradient spectrometry

1998-06-08

2000-04-11

Westin, Edward P.

Radiant energy

Invisible radiant energy responsive electric signalling

Infrared responsive

2502521, 25033907, 2503416, 2503418, G01N 2171

Patent

active

060490810

ABSTRACT:
Spectrometric methodology for non-invasively obtaining optical spectra from heterogeneous material for the identification and quantification of constituent compounds. There is provided a transient or steady state subsurface thermal gradient spectroscopic methodology for obtaining in vivo optical spectra relating to the concentration of n analytes at depths to around 330 microns in human tissue, and for determining that concentration from the spectra. The methodology is employable on a wide variety of spectrometric devices, and enables: a real time determination of both surface and reference intensities; a fast, efficient calibration of the spectrometric device; and results in the provision of an analytical parameter which avoids the measurement of the optical path length to enable the extremely accurate calculation of a ratio of concentrations of n analytes in the system under analysis.

REFERENCES:
patent: 5461229 (1995-10-01), Sauter et al.
patent: 5900632 (1999-05-01), Sterling et al.

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