Phospholipase C homolog

Details Phospholipase C homolog Phospholipase C homolog

1995-04-10

1996-12-24

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

43525233, 4353201, 536 232, C12N 920, C12N 1554, C12N 1570

Patent

active

055873065

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for the detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.

REFERENCES:
Ho et al., "Interleukin 4 Receptor Signaling in Human Monocytes and U937 Cells Involves the activation of a phosphatidylchloline-Specific Phospholipase C: A Comparison with Chemotactic Peptide, FMLP, Phospholipase D, and Sphingomyelinase," J Exper Med 180:1457-69 (1994).
Katz et al., "Subunits .beta..gamma. of heterotrimeric G protein activate .beta.2 isoform of phospolipase C," Nature 360:686-9 (1992).
Yeo et al., "Activation of Phospholipase C-.gamma. Is Necessary for Stimulation of Phospholipase D by Platelet-derived Growth Factor," J Biol Chem 269(45):278323-27826 (Nov. 1994).
Deans et al., "Association of Tyrosine and Serine Kinases with the B Cell Surface Antigen CD20," J. Immunol 151(9):4494-4504 (Nov. 1993.
Marrero et al., "Angiotensin II Stimulates Tyrosine Phosphorylation of Phospholipase C-.gamma.1 in Vascular Smooth Muscle cells," J. Biol Chem 269:10935-39 (Apr. 1994).
Isselbacher et al., Harrison's Principles of Internal Medicine, McGraw-Hill, New York City (1994), pp. 428-430.
Kuruvilla et al., "Tyrosine Phosphorylation of Phospholipase C Concomitant with Its Activation by Platelet-Activating Factor in a Human B Cell Line," J Immun 151:637-648 (1993).
Rhee et al, "Regulation of Inositol Phospholipid-specific Phospholipase C Isozymes," J Biol Chem 267:12393-12396 (1992).

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