Substituted arylalkylamines as neurokinin antagonists

Details Substituted arylalkylamines as neurokinin antagonists Substituted arylalkylamines as neurokinin antagonists

1996-10-28

1998-08-04

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514255, 514318, 514319, 514323, 514324, 514329, 514330, 514331, 544336, 544405, 544408, 544409, 546188, 546193, 546194, 546201, 546207, 546208, 546209, 546214, 546217, 546221, 546225, 546228, 546229, 546231, 546324, 546331, A61K 31445, C07D21122

Patent

active

057894221

ABSTRACT:
Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof are disclosed, wherein: A.sup.1 is --CH.sub.2 R.sup.6, --OR.sup.6, --N(R.sup.6)(R.sup.7), --S(O).sub.e R.sup.13, --(C(R.sup.6)(R.sup.7)).sub.1-6 --OR.sup.6, --(C(R.sup.6)(R.sup.7).sub.1-6 --N(R.sup.6)(R.sup.7) or --(C(R.sup.6) (R.sup.7)).sub.1-6 --S(O).sub.e R.sup.13 and A.sup.2 is H, or A.sup.1 and A.sup.2 together are .dbd.O, .dbd.C(R.sup.6)(R.sup.7), .dbd.NOR.sup.6 or .dbd.S;

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Maggi et al, Eur. J. Pharmacol., 166, (1989), pp. 435-440.
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Danko et al, Pharmacol. Comm., 1, 3 (1992), pp. 203-209.
Chung et al, Molecular Pharmacol., 48 (1995), pp. 711-716.
Abstract of FR 2,717,802.

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