High-dose chromium/biotin treatment of type II diabetes

Details High-dose chromium/biotin treatment of type II diabetes High-dose chromium/biotin treatment of type II diabetes

1997-08-08

1998-08-04

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514387, A61K 31555, A61K 31415

Patent

active

057894019

ABSTRACT:
A method for treating Type II diabetes by administering to an affected individual a combination of chromic tripicolinate and biotin at doses far beyond the nutritional requirements. The two compounds are administered orally or parenterally at in daily dosages which provide between 1,000 and 10,000 .mu.g of chromium and between 1 mg and 200 mg biotin.

REFERENCES:
patent: 4315927 (1982-02-01), Evans
patent: 5087623 (1992-02-01), Boynton et al.
Coggeshall, J., et al. (1985) Biotin status and plasma glucose in diabetics. Ann. N.Y. Acad. Sci. 447:387-392.
Maebashi, M., et al. (1993) Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus. J. Clin. Biochem. Nutr. 14:211-218.
Mock, D. in Present Knowledge in Nutrition, seventh edition, Chapter 22, pp. 220-235
Reddi, A., et al. (1988) Biotin supplementation improves glucose and insulin tolerances in genetically diabetic kk mice. Life Sciences 42: 1323-1330.
Zhang, H., et al. (1996) A high biotin improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus. J. Nutr. Sci. Vitaminol. 42: 517-526.
Zhang, H., et al. (1997) Biotin administration improves the impaired glucose tolerance of streptozotocininduces diabetic Wistar rats. J. Ntr. Sci. Vitaminol. 43(3):271-280.

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