Process of preparing particles for NMR imaging

Details Process of preparing particles for NMR imaging Process of preparing particles for NMR imaging

1995-04-13

1996-12-24

Dudash, Diana

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Analysis, diagnosis, measuring, or testing product

427 214, 427220, 427600, B05D 700, B05D 312, B32B 900, B06B 100

Patent

active

055871992

ABSTRACT:
Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

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