Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-01-06
1998-08-04
Carlson, Karen C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514832, 530385, 530402, 530409, 530410, 530829, A61K 3714, C07K 14805
Patent
active
057893764
ABSTRACT:
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. The formulations described herein interact with free radicals, act as antioxidant enzyme-mimics, and alleviate oxidative stress and oxygen-related toxicity.
REFERENCES:
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4136093 (1979-01-01), Bonhard et al.
patent: 4240797 (1980-12-01), Hsia
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4376095 (1983-03-01), Hasegawa
patent: 4377512 (1983-03-01), Ajisaka et al.
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4473494 (1984-09-01), Tye
patent: 4473496 (1984-09-01), Scannon
patent: 4529719 (1985-07-01), Tye
patent: 4563349 (1986-01-01), Miyata et al.
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4598064 (1986-07-01), Walder
patent: 4600531 (1986-07-01), Walder
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4780210 (1988-10-01), Hsia
patent: 4783400 (1988-11-01), Davis et al.
patent: 4826811 (1989-05-01), Sehgal et al.
patent: 4831012 (1989-05-01), Estep
patent: 4834964 (1989-05-01), Rosen
patent: 4845090 (1989-07-01), Gries et al.
patent: 4857636 (1989-08-01), Hsia
patent: 4863717 (1989-09-01), Keans
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4911929 (1990-03-01), Farmer et al.
patent: 4920194 (1990-04-01), Feller et al.
patent: 4925574 (1990-05-01), Hsia
patent: 4925652 (1990-05-01), Gries et al.
patent: 5023072 (1991-06-01), Cheng
patent: 5061688 (1991-10-01), Beissinger et al.
patent: 5080645 (1992-01-01), Hanig
patent: 5104641 (1992-04-01), Rosen
patent: 5114932 (1992-05-01), Runge
patent: 5128121 (1992-07-01), Berg et al.
patent: 5234903 (1993-08-01), Nho et al.
patent: 5250672 (1993-10-01), Sadler et al.
patent: 5256397 (1993-10-01), Rosen
patent: 5314681 (1994-05-01), Leunbach et al.
patent: 5368840 (1994-11-01), Unger
patent: 5407657 (1995-04-01), Unger et al.
patent: 5494030 (1996-02-01), Swartz et al.
patent: 5505932 (1996-04-01), Grinstaff et al.
"Nitroxide-Stimulated H.sub.2 O.sub.2 Decomposition by Peroxidases and Pseudoperoxidases"; Rolf J. Mehlhorn and Christopher E. Swanson, Free Rad. Res. Comms. v17, N3, pp.157-175.
"Nitric Oxide, an Inhibitor of Lipid Oxidation by Lipoxygenase, Cycloosygenase, and Hemoglobin"; Joseph Kanner, Stela Harel, and Rina Granit, Lipids, 1992, v27, N1, pp. 46-49.
"Inhibition of Lipid Peroxidation by Spin Labels--Relationships Between Structure and Function"; Ulf A. Nilsson, Lars-Inge Olsson, Gunnar Carlin, and Ann-Christin Bylund-Fellenius, The Journal of Biological Chemistry, 1989, v264 pp. 11131-11135 (1989).
"Preservation of Metabolic Activity in Lyophilized Human Erythrocytes"; R. Goodrich, et al., Proc. Natl. Acad. Sci., 89 967-971 (1992).
"Nitroxides as Protectors Against Oxidative Stress"; James B. Mitchell and Angleo Russo Presented at New developments in free radical research: Prospects for New Drugs Conference Jun. 27-28, 1991, Philadelphia, PA. Sponsored by International Business Communications.
"Superoxide Reaction with Nitroxides"; Amram Samuni, C. Murali Krishna, James B. Mitchell, Christi R. Collins, and Angelo Russo, Free Rad. Res. Comms., 1990, v9, pp. 241-249.
"Sterically-Hindered hydroxylamines as Bioactive Spin labels"; Renat I. Zhdanov, and Pavel G. Komarov, Free Rad. Res. Comms, 1990, v9, pp. 367-377.
"SOD-Like activity of 5-Membered Ring Nitroxide Spin Labels"; Amram Samuni, Ahn Min, C. Murali Krishna, James B. Mitchell, and Angelo Russo, Antioxidants in Therapy and Preventive Medicine, 1990, pp. 85-92.
"Biologically Active Metal-Independent Superoxide Dismutase Mimics"; James B. Mitchell, Amram Samuni, Murali C. Krishna, William G. DeGraff, Min S. Ahn, Uri Samuni, and Angelo Russo, Biochemistry, 1990, v29, pp. 2802-2807.
"Cardiac Reperfusion Damage Prevented by a Nitroxide Free Radical"; Dan Gelvan, Paul Saltman, and Saul R. Powell, Proc. Natl. Acad. Sci., 1991, v88, pp. 4680-4684.
"Nitroxide Block DNA Scission and Protect Cells from Oxidative Damage"; Amram Samuni, Dina Godinger, Jacob Aronovitch, Angelo Russo, and James B. Mitchell, Biochemistry, 1991, v30, pp. 555-561.
"Nitroxide Stable Radicals Protect Beating Cardiomyocytes Against Oxidative Damage"; Amram Samuni, Dorit Winkelsberg, Arie Pinson, Stephen M. Hahn, James B. Mitchell, and Angelo Russo, The Journal of Clinical Investigation, Inc., 1991, v87 pp. 1526-1530.
"Detection of Myoglobin-Derived Radicals on Reaction of Metmyoglobin with Hydrogen Peroxide and Other Peroxidic Compounds"; Michael J. Davies (1990), Free Rad. Res. Comms., 1990, v10, N6, pp. 361-370.
"Perspectives on Hydrogen Peroxide and Drug-Induced Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency"; Paul Hochstein, Free Radical Biology & Medicine, 1988, v5, pp. 387-392.
"Mechanisms and Consequences of Lipid Peroxidation in Biological Systems"; Alex Sevanian and Paul Hochstein, Ann. Rev. Nutr., 1985, v5, pp. 365-390.
"Uric Acid Provides an Antioxidant Defense in Humans Against Oxidant-and Radical-Caused Aging and Cancer: A Hypothesis"; Bruce N. Ames, Richard Cathcart, Elizabeth Schwiers, and Paul Hochstein, Proc. Natl. Acad. Sci. USA, 1981, v78, N11, pp. 6858-6862.
"In Vivo Rat Hemoglobin Thiyl Free Radical Formation Following Phenylhydrazine Administration"; Kirk R. Maples, Sandra J. Jordan, and Ronald P. Mason, Molecular Pharmacology, 1988, v33, pp. 344-350.
"Autoxidation of Oxymyoglobin--An Overall Stoichiometry Including Subsequent Side Reactions"; Gen-ichi Tajima and Keiji Shikama, The Journal of Biological Chemistry, 1987, v262, pp. 12603-12606.
"A Novel Antioxidant Role for Hemoglobin--The Comproportionation of Ferrylhemoglobin with Oxyhemoglobin"; Cecilia Giulivi and Kelvin J.A. Davies, The Journal of Biological Chemistry, 1990, v265, pp. 19453-19460.
"The Reactivity of Thiols and Disulfides with Different Redox States of Myoglobin--Redox and Addition Reactions and Formation of Thiyl Radical Intermediates"; Francisco J. Romero, Ishmael Ordonez, Arduino Arduini, and Enrique Cadenas, The Journal of Biological Chemistry, 1992, v267, pp. 1680-1688.
"The Special Role of Myoglobin in Cardiac Ischemia-Reprefusion Injury"; Paul Hochstein and Arduino Arduini, Symposium on Biological Free Radicals, Udine, Italy, Jul. 1-5 (1991).
A Protective Role for Ascorbate in Induced Ischemic Arrest Associated with Cardiopulmonary Bypass; Lynne Eddy, Richard Hurvitz, and Paul Hochstein, Journal of Applied Cardiology, 1990, v5, pp. 409-411.
"Pulse Radiolysis Study on the Reactivity of Trolox C. Phenoxyl Radical with Superoxide Anion"; Enrique Cadenas, Gabor Merenyi, and Johan Lind, FEBS Letters, 1989, v253, N1-2, pp. 235-238.
"Reversible Conversion of Nitroxyl Anion to Nitric Oxide by Superoxide Dismutase"; MNichael E. Murphy and Helmut Sies, Proc. Natl. Acad. Sci. USA, 1991, v88, pp. 10860-10864.
"A Human Recombinant Haemoglobin Designed for Use as a Blood Substitute"; Douglas Looker, Debbie Abbott-Brown, Paul Cozart, Steven Durfee, Stephen Hoffman, Antony J. Matthews, Jeanne Miller-Roehrich, Steven Shoemaker, Stephen Trimble, Giuilio Fermi, Noboru H. Komiyama, Kiyoshi Nagai, and Gary L. Stetler, Nature, 1992, v356, pp. 258-260.
"Review Article--Mechanisms of Cardiovascular Drugs as Antioxidants", J. Mol Cell Cardiol, 1990, v22, pp. 1199-1208.
"Biochemistry of Oxygen Toxicity"; Enrique Cadenas, Annu. Rev. Biochem., 1989, v58, pp. 79-110.
"A Novel Metal-Free Low Molecular Weight Superoxide Dismutase Mimic"; Amram Samuni, C. Murali Krishna, Peter Riesz, Eli Finkelstein, and Angelo Russo, The Journ
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