Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-06-18
2000-04-11
Jones, Dwayne C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A01N 4346
Patent
active
060488557
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a cosmetic, dermatological and/or pharmaceutical composition intended in particular for the treatment in man of certain cutaneous disorders and/or skin diseases, in particular painful and/or pruriginous diseases.
Some of these diseases are currently treated by means of local corticoids or of PUVA therapy. Corticoids are very effective in soothing the symptoms of these diseases but, unfortunately, they exhibit side effects which are often highly disadvantageous, such as atrophies or infections, in particular mycotic or bacterial infections. PUVA therapy is, for its part, the local irradiation of the diseased skin with UVA radiation, after absorption of a photosensitizing substance. This technique exhibits the serious disadvantages of a photoageing, which can very often result in cancers of the skin. Moreover, this treatment is not ambulatory, obliging the patients commonly to go to a specialist centre throughout the duration of the treatment, which is highly restricting and limits their occupational employment and their leisure activities.
The precise subject of the present invention is a topical composition which makes it possible to effectively treat these cutaneous diseases, while overcoming these disadvantages.
Moreover, it is known that certain skins are more sensitive than others. Now, the symptoms of sensitive skins were, until now, poorly characterized and no one knew exactly the process implicated in the sensitivity of the skin. Some thought that a sensitive skin was a skin which reacted to cosmetic or pharmaceutical products, others that it was a matter of a skin which reacted to a number of external factors, not necessarily related to cosmetic products.
Some tests were tried in attempting to define sensitive skins, for example tests with lactic acid and with DMSO, which are known to be irritant substances: see, for example, the article by K. Lammintausta et al., Dermatoses, 1988, 36, pages 45-49; and the article by T. Agner and J. Serup, Clinical and Experimental Dermatology, 1989, 14, pages 214-217. However, these tests did not make it possible to characterize sensitive skins.
Moreover, sensitive skins were classified as allergic skins.
Due to this ignorance of the characteristics of sensitive skins, it was, until now, very difficult to treat them, and they were treated indirectly, for example by limiting the employment in cosmetic or dermatological compositions of products with an irritant nature, such as surfactants, preservatives or fragrances.
After many clinical tests, the Applicant has been able to determine the symptoms related to sensitive skins. These symptoms are in particular subjective signs which are essentially dysaesthetic sensations. Dysaesthetic sensations is understood to mean more or less painful sensations felt in a cutaneous region, such as smarting, pins and needles, itching or pruritus, burning sensations, warming sensations, discomfort, stabbing pains, and the like.
In addition, the Applicant has been able to show that a sensitive skin was not an allergic skin. In fact, an allergic skin is a skin which reacts to an external agent, known as an allergen, which triggers an allergic reaction. This relates to an immunological process which only takes place in the presence of an allergen and which only affects sensitized subjects. In contrast, the essential characteristic of sensitive skin is, according to the Applicant, a mechanism of response to external factors which can concern any individual, even if individuals said to have sensitive skins react thereto faster than other individuals. This mechanism is not immunological.
The Applicant has now found that sensitive skins could be divided into two major clinical forms: irritable and/or reactive skins and intolerant skins.
An irritable and/or reactive skin is a skin which reacts by a pruritus, that is to say by itching or by smarting, to different factors, such as the environment, the emotions, food, the wind, friction, shaving, soap, surfactants, hard water with a high calcium concentration, t
REFERENCES:
Rumsfield et al. DICP Ann. pharmacother., 25(4), 381-7 (Abstract), 1991.
Lou et al. Biochem. Biophys. Res. Commin., 189(1), 537-44 (Abstract), 1992.
Wang et al. Br. J. Pharmacol., 110(3), 1073-8 (Abstract), 1993.
Br. J. Pharmacol., vol. 107, No. 2, 1992, pp. 329-333, XP000576708, M.N. Perkins: "Capsazepine reversal of the antinociceptive action of capsaicin in vivo."
Breton Lionel
De Lacharriere Olivier
Jones Dwayne C.
Societe l'Oreal S.A.
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