Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1997-01-17
1998-08-04
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435 6, 4353201, 4352523, 43525411, 435325, 536 232, C12N 900, C12N 1500, C12N 120, C07H 2104
Patent
active
057892180
ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
REFERENCES:
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Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85 pp. 3604-3607 (1988).
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Borgford, et al., "The valyl-tRNA synthetase from Bacillus stearothermophilus has considerable sequence homology with the isoleucyl-tRNA synthetase", EMBL Sequence Database, Accession No. M16318, and Biochemistry, 26, No. 9,pp. 2480-2486 (1987).
Putzer, et al., "Bacillus subtilis valyl-tRNA synthetase", EMBL Sequence Database, Accession No. X77239, and J. Bacteriol., 175, No. 2, pp. 528-540 (1993).
Taylor et al. (1993) Cloning and Sequence Determination of the valS Gene, Encoding Valtyl-tRNA Synthetase in Lactobacillus casei. J. Bacteriol. 175(8): 2475-2478.
Hodgson John Edward
Lawlor Elizabeth Jane
Gimmi Edward R.
Hobbs Lisa J.
King William T.
Lentz Edward T.
SmithKline Beecham p.l.c.
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