Human ETS family member, ELF3

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 701, 4352402, 4352523, 4353201, 536 231, C12P 2106, C07H 2102, C07H 2104, C12N 1500

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active

057892008

ABSTRACT:
Human ELF3 polypeptides and DNA (RNA) encoding such ELF3 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ELF3 for the diagnosis and treatment of cancers, in particular prostate, breast, lung or other epithelial tumors, among others.

REFERENCES:
patent: 5580958 (1996-12-01), Maki et al.
patent: 5629192 (1997-05-01), Suzuki et al.
Ngo et al. (Jan. 1994) Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, In: The Protein Folding Problem and Tertiary Structure Prediction, Eds. Merz and Le Grand, Birkhauser, Boston, MA, pp. 491-495.
Burtis, Thummel, Jones, Karim, Hogness; "The Drosophia 74EF Early Puff Contains E74, a Complex Ecdysone-Inducible Gene That Encodes Two ets-Related Proteins"; Cell, vol. 61, Apr. 6, 1990; pp. 85-99.
Leiden, Wang, Petryniak, Markovitz, Nabel, Thompson; "A Novel Ets-Related Transcription Factor, Elf-1, Binds to Human Immunodeficiency Virus Type 2 Regulatory Elements That Are Required for Inducible trans Activation in T Cells"; Journal of Virology, Oct. 1992; pp. 5890-5897.
Oettgen, Akbarali, Boltax, Best, Kunsch, Libermann; "Characterization of NERF, a Novel Transcription Factor Related to the Ets Factor ELF-1"; Molecular and Cellular Biology, Sep. 1996; pp. 5091-5160.

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