Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-06-18
1999-10-05
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514474, 514718, A61K 31505, A61K 3134, A61K 31075
Patent
active
059624612
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This present invention relates to a liquid drug composition, and more particularly to a pleasant-tasting aqueous liquid pharmaceutical composition that contains an otherwise bitter-tasting drug.
BACKGROUND ART
Many useful, effective drugs have a bitter taste when dissolved in liquid form or even when administered as pills or tablets. Exemplary of such drugs are acetaminophen, terfenadine, guaifenesin, trimethoprim, prednisolone, ibuprofen, prednisolone sodium phosphate, methacholine, neostigmine, epinephrine, albuterol, pseudoephedrine hydrochloride, diphenhydramine, chlorpheniramine maleate, phenothiazine, chlorpromazine, chlordiazepoxide, amitriptyline, barbiturates, diphenylhydantoin, caffeine, morphine, demerol, codeine, lomotil, lidocaine, salicylic acid, sulfonamides, chloroquine, a vitamin preparation, minerals and penicillins. These and other bitter-tasting drugs are consequently usually formatted for oral administration as coated pills or tablets or as a powder or prills within a capsule so that the bitter-tasting medicament does not contact the tongue during oral administration.
Although provision in an above coated tablet or pill form or within a capsule overcomes the problem of offensive taste for several valuable medicaments for most of the adult population that uses those drugs, many adults and many children have difficulty swallowing the pills or tablets or cannot swallow them, and thereby do not benefit from those drugs. Recently issued U.S. Pat. No. 5,455,049 illustrates one technique that was successful in overcoming the bitter taste problem associated with orally administered terfenadine.
The disclosure that follows illustrates another, more general solution to both of the problems of bitter taste and oral administration of a solid dosage form such as a pill or capsule that is applicable to adults and children that have difficulty swallowing or cannot swallow pills, capsules and the like, as well as an alternative delivery mode for the general population.
BRIEF SUMMARY OF THE INVENTION
A transparent liquid pharmaceutical composition is contemplated by the present invention. That composition comprises a pharmaceutically effective amount of a bitter-tasting drug that is dissolved or dispersed in an aqueous medium that is free of ethanol. That aqueous medium consists essentially of water, about 5 to about 30 weight percent polyvinylpyrrolidone (PVP), about 35 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants. The aqueous liquid composition is transparent and has a pleasant taste when orally administered; i.e., it is free from having a bitter taste that would otherwise be associated with the bitter-tasting drug.
In preferred practice, the drug is present in an amount of about 0.5 to about 5 weight percent and the ammonium glycyrrhizinate is present in a weight ratio relative to the drug of about 1:50 to about 2:1, and preferably at about 1:50 to about 1:10. Preferably, the PVP is present at about 5 to about 20, and more preferably at about 7 to about 15 weight percent, the drug at about one to about 3 weight percent, with the glycyrrhizinate present at the before-noted weight ratio to the drug, and most preferably at a weight ratio to the drug of about 1:20.
The present invention has several benefits and advantages.
One benefit is that a contemplated composition has a pleasant taste that permits it to be administered to children without the usually observed reluctance of children to take the bitter-tasting drug.
An advantage of the invention is that the bitter drug-containing composition is provided as a liquid to that it can be taken by those persons that have difficulty swallowing or cannot swallow usual solid forms of the drug such as a pill, tablet or capsule.
Another benefit of the invention is that a contemplated composition is free of ethanol so that it can be taken by children to whom an ethanol-containing pharmaceutical composition would normally not be given.
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REFERENCES:
patent: 2909522 (1959-10-01), Hitchings et al.
patent: 4303643 (1981-12-01), Armstrong
patent: 4393200 (1983-07-01), Miyashita et al.
patent: 5154926 (1992-10-01), Kawasaki et al.
patent: 5455049 (1995-10-01), Anaebonam et al.
Horn et al. J. Pharm. Sci., 71: 1021-1026 (1982).
Buhler, Kollidon, BASF, Aktiengesellshaft, Ludwigshafen, Germany, pp. 39-42, 70-72, 113-115 (1992).
Gennaro, Alfonso R., ed., Remington's Pharmaceutical Sciences, 18.sup.th ed., Mack Publishing Company (Easton, Pennsylvania: 1989), pp. 1290-1296.
Dhabhar et al., World Patent Index Abstracts, AN C95-122039 Abstract of WO/95/19759, 1995.
Budavari, Susan, ed., The Merck Index, 11.sup.th Ed., Merck & Co., Inc. (Rahway), NJ: 1989, pp. 132, 1321.
Dorland's Illustrated Medical Dictionary 27.sup.th Ed., W.B. Saunders Co., Philadelphia (1988), p. 1231.
Budavari et al., eds., The Merck Index, 11.sup.th Ed., p. 1274 (1989).
Anaebonam Aloysius O.
Clemente Emmett
Fawzy Abdel A.
Ascent Pediatrics Inc.
Jarvis William R. A.
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