Certain substituted benzylamine derivatives a new class of neuro

Details Certain substituted benzylamine derivatives a new class of neuro Certain substituted benzylamine derivatives a new class of neuro

1997-07-18

1999-10-05

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 514253, 514255, 540470, 540575, 544356, 544359, 544295, 544360, 544362, 544363, 544370, 544393, A61K 31495, C07D295135, C07D40112, C07D40310

Patent

active

059624558

ABSTRACT:
This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X.sub.1, X.sub.2, X.sub.3 represent organic or inorganic substituents, n is 1, 2, or 3, m is 2, 3, or 4, R.sub.1 -R.sub.4 are hydrogen or organic substituents, and B is nitrogen, carbon, sulfur or oxygen, useful in the diagnosis and treatment of feeding disorders such as obesity and bulimia and cardiovascular diseases such as essential hypertension and congestive heart failure due to the binding of these compounds to mammalian Neuropeptide Y1 receptors.

REFERENCES:
Gehlert et al., Exp. Opin. Invest Drugs, 6 (12), pp. 1827-1838, 1997.
Grundemar et al, TIPS 15, pp. 153-159, 1994.

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