Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-11-26
1999-10-05
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 530324, 530345, 530402, 530406, A61K 3800, C07K 100
Patent
active
059624140
ABSTRACT:
Composition and method for suppression and inhibition of carcinogenesis comprising a modified Bowman-Birk inhibitor (BBI) comprising an active chymotrypsin inhibitory site, and a deactivated trypsin inhibitory site. The modified Bowman-Birk Inhibitor has been prepared by specifically acetylating a lysine residue with acetic anhydride.
REFERENCES:
patent: 5616492 (1997-04-01), Kennedy et al.
Seidl et al., Biochim. Biophys. Acta, 251(1), "Identification of the Trypsin-Reactive Site of the Bowman-Birk Soybean Inhibitor", pp. 83-93, in Chem. Abstr., 76:43286, 1971.
Madar, Z., Br. J. Nutr., 42(1), "Kinetics of Native and Modified Bowman-Birk Soybean Trypsin Inhibitor on Growth and Enzymes Activities of the Chick Pancreas", pp. 121-126, in Chem. Abstr. 92:1386, 1979.
Smirnoff et al., Int. J. Pept. Protein Res., 26(3), "Preparation of Photoreactive Derivatives of Trypsin-Chymotrypsin Inhibitors from Soybeans and Chick Peas by Selective Modification of Lysine Residues", pp. 274-278, in Chem. Abstr. 103:209708, 1985.
Birk et al., Adv. Exp. Med. Biol., 199(Nutr. Toxicol. Signif. Enzyme Inhib. Foods), "Photoreactive, Active Derivatives of Trypsin and Chymotrypsin Inhibitors from Soybeans and Chickpeas", pp. 469-481, in Chem. Abstr., 107:35681, 1986.
Ohba et al., Biosci., Biotechnol., Biochem., 62(6), "Cytotoxicity Induced by Erythrina Variegata Serine Proteinase Inhibitors in Tumor Hematopoietic Stem Cell Lines", pp. 1166-1170, inChem. Abstr. 129:197697, Jun. 1998.
Kay, UCLA-12-1167, "Structure-Function Relationships of Proteinase from Soybean (Bowman-Birk) and Lima Bean: Modification by N-Acetylimidazole", in Chem. Abstr. 92:2267, 1978.
Kay, E., J. Biol. Chem., 254(16), "Structure-Function Relationships of Proteinase Inhibitors from Soybean (Bowman-birk) and Lima Bean. Modification by N-Acetylimidazole", pp. 7648-7650, Aug. 1979.
Sarma et al., Indian J. Biochem. Biophys., 28(5-6), "Nature of the Tryptic/Chymotryptic Inhibitor from Horsegram (Dolichos Biflorus)", pp. 418-424, in Chem. Abstr. 116:79139, 1991.
Ekrami et al., FEBS Letters, 371(3), "Water-Soluble Fatty Acid Derivatives as Acylating Agents for Reversible Lipidization of Polypeptides", pp. 283-286, Sep. 1995.
Kay, E., J. Biol. Chem., 254(16), "Lima Bean Proteinase Inhibitor. Origins of Circular Dichroism Bands and Modification by Br2-and (CNS)2-", pp. 7643-7647, Jun. 1976.
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