Human growth hormone variants and methods of administering same

Details Human growth hormone variants and methods of administering same Human growth hormone variants and methods of administering same

1996-09-16

1999-10-05

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 530399, 530397, 530350, 435 691, 435 694, 435 697, C07K 1400, C07K 1461, A61K 3816, A61K 3827

Patent

active

059624116

ABSTRACT:
There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.

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