Histamine H.sub.2 -antagonists

Details Histamine H.sub.2 -antagonists Histamine H.sub.2 -antagonists

1983-05-19

1985-04-09

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602444, 546193, 546256, 546277, C07D41712, C07D41714

Patent

active

045103097

ABSTRACT:
Histamine H.sub.2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R.sup.1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2, n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

REFERENCES:
patent: 4062863 (1977-12-01), Ganellin
patent: 4104381 (1978-08-01), Durant
patent: 4394508 (1983-07-01), Crenshaw

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