Human and rat gamma glutamyl hydrolase antibodies

Details Human and rat gamma glutamyl hydrolase antibodies Human and rat gamma glutamyl hydrolase antibodies

1998-08-04

1999-10-05

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

5303871, 5303881, 53038815, 53038826, 5303891, G01N 3353, A61K 39395

Patent

active

059622350

ABSTRACT:
The present invention is directed to isolated nucleic acid molecules encoding gamma glutamyl hydrolase (GH). Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of GH in host cells. The invention further provides a method of screening a substance for the ability of the substance to modify GH function, and a method for isolating other GH molecules. DNA oligomers and antibodies specific for GH are provided, each of which can be used to detect GH in a sample. Methods for decreasing deleterious side effects of antifolate treatment, increasing the levels of GH in cells of a patient, increasing the effectiveness of antifolate treatment, and monitoring progression of a tumor are further provided.

REFERENCES:
Israeli, R.S., et al., Cancer Research 53:227-230 (1993).
Pinto, J.T., et al., Clinical Cancer Research 2(9):145-1451 (1996).
Leek, J., et al., Br J Cancer 72(3):583-588 (1995).
Silver, D.A., et al., Clinical Cancer Research 3:81-85 (1997).
Chandler et al., Am J Physiol 260:G865-G872 (1991).
Wang et al., Biochim Biophys Acta 1164:227-235 (1993).
McGuire, J.J. and Coward, J.K., in "Folates and Pterins: Vol. 1 Chemistry and Biochemistry of Folates", Blakely, R.L. and Benkovic, eds., John Wiley & Sons, Inc., New York, pp. 135-190 (1984).
Acc. #T26504, n-gene seq. database.
Acc. # N45706, R77701, N53343, H09442, and N48195, EST database (Hillier et al.).
Tao et al. J. Biol. Chem. 271:8525-8528, Apr. 12, 1996.

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