Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-09-30
1999-10-05
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 4352523, 43525411, 435325, 435410, 435 691, 435193, 536 232, C12Q 168, C12N 100, C12N 510, C12N 910, C12N 1554, C12N 1563
Patent
active
059622318
ABSTRACT:
The invention provides a human glutathione-S-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HGST.
REFERENCES:
Thier, R., et al., "Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes", Proc Natl Acad Sci USA, 90: 8576-8580 (1993).
Simula, T.P., et al., "Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1", Carcinogenesis, 14: 1371-1376 (1993).
Dirven, H.A., et al., "Involvement of Human Glutathione S-transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione", Cancer Res, 54: 6215-6220 (1994).
Yokomizo, A., et al., "Markedly Decreased Expression of Glutathione S-Transferase .PI. Gene in Human Cancer Cell Lines Resistant to Buthionine Sulfoximine, and Inhibitor of Cellular Glutathione Synthesis", J Biol Chem, 270: 19451-19457 (1995).
Kodym, R., et al., (GI 1899207) GenBank Sequence Database (Accession U90313), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (1899208).
Corley Neil C.
Shah Purvi
Yue Henry
Billings Lucy J.
Bugaisky Gabriele E.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Wax Robert A.
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