Substituted aminobenzamides and their use as agents which inhibi

Details Substituted aminobenzamides and their use as agents which inhibi Substituted aminobenzamides and their use as agents which inhibi

1984-01-06

1985-04-09

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544165, 546226, 548539, 564163, 564167, 514329, 514426, 514826, C07D29518, C07C10322, C07C10329, C07C10385

Patent

active

045101396

ABSTRACT:
Novel 2-(hydroxyphenylamino)benzamides and oxidation products thereof, useful as inhibitors of lipoxygenase, are of the formulas ##STR1## wherein R is hydrogen, lower-alkyl, halo or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and N.dbd.Z is amino or substituted amino. The compounds of Formula I are prepared by de-etherification of the corresponding alkyl or benzyl ethers; and the compounds of Formula II are prepared by oxidation of the compounds of Formula I where R' is hydrogen and OH is in the 4-position.

REFERENCES:
patent: 4093734 (1978-06-01), Kruger et al.
Dong Han Kim, J. Heterocyclic Chem., vol. 18, (1981), pp. 1389-1392.
H. Brockmann et al., Chem. Ber., vol. 104, (1971), pp. 2751-2771.
Chatterjee et al., J. Indian Chem. Soc., 46, 103-108, (1969).
Chen et al., J. Med. Chem., 21, 868-874, (1978).
Juby et al., J. Med. Chem., 11, 111-117, (1968).
Cain et al., J. Med. Chem., 18, 1110-1117, (1975).
G. Ege, Chem. Ber., 101, 3079-3088, (1968).
Legrand et al., Bull. Soc. Chim., France, 1973, (pt. 2), 1665-1667.
Legrand et al., Bull. Soc. Chim., France, 1975, (pt. 2), 1415-1418.
Iwao et al., J. Am. Chem. Soc., 104, 5531-5533, (1982).

Affiliated with

Also associated with

Rating

Substituted aminobenzamides and their use as agents which inhibi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted aminobenzamides and their use as agents which inhibi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted aminobenzamides and their use as agents which inhibi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1169190