Orally administered heparin

Details Orally administered heparin Orally administered heparin

1982-04-21

1985-04-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 514822, A61K 3173, A61K 31725, C08B 3710

Patent

active

045101353

ABSTRACT:
An orally administrable heparin comprising: a complex of heparin with (1) a protonated tertiary organic ammonium ion having the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a branched or unbranched alkyl group of 1 to 12 carbon atoms, which may be unsubstituted or substituted with hydroxy or alkoxy groups, or R.sup.1 and R.sup.3 together with the N atom can form a pyrrolidine, imidazole or morpholine ring; or (2) an ester-containing quaternary ammonium ion having the formula: ##STR2## wherein R.sup.4, R.sup.5 and R.sup.6 each independently represent a branched or unbranched alkyl group of 1 to 12 carbon atoms, which may be unsubstituted or substituted with hydroxy or alkoxy groups, or R.sup.4 and R.sup.6 together with the N atom can form a pyrrolidine, imidazole or morpholine ring;

REFERENCES:
patent: 2989438 (1961-06-01), Nomine et al.
patent: 3058884 (1962-10-01), Mozen et al.
patent: 3160563 (1964-12-01), Nazzareno
patent: 3232837 (1966-02-01), Nomine et al.
patent: 3337409 (1967-08-01), Williams
patent: 4302368 (1981-11-01), Dudley et al.

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