Process for preparing N6,9-disubstituted adenine

Details Process for preparing N6,9-disubstituted adenine Process for preparing N6,9-disubstituted adenine

1982-09-17

1990-02-13

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D47334

Patent

active

049008269

ABSTRACT:
A process for preparing N.sup.6, 9-disubstituted adenines which comprises reacting a metal salt of N.sup.6 -substituted adenine with a benzyl halide compound, preferably in the presence of a phase transfer catalyst. According to the process, the N.sup.6,9-disubstuted adenines can be obtained in high yields and good selectivity.

REFERENCES:
patent: 4100159 (1978-07-01), Zwan
patent: 4174440 (1979-10-01), Shinkai et al.
patent: 4189485 (1980-02-01), Matsuno et al.
Melvin Sutherland et al., J. Am. Chem. Soc., vol. 79, pp. 2251-2252 (1957).
Starks et al., Phase Transfer-Catalyst, Principles and Techniques 1978, Academic Press, New York, pp. 1-12, 58-59, 77-82 112-117 and 217-223.
Starks, "Chemtech", 1980, pp. 110-117.
Ford, "Chemtech", 1984, pp. 436-439.

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