Resinate of a substituted carboxylic acid, the preparation and u

Details Resinate of a substituted carboxylic acid, the preparation and u Resinate of a substituted carboxylic acid, the preparation and u

1984-01-06

1985-04-09

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 78, 521 32, 5253322, A61K 3174

Patent

active

045101280

ABSTRACT:
A resinate of the formula ##STR1## wherein Am.sup..sym. is a strongly basic copolymer of styrene and divinylbenzene which is in cationic form, said copolymer containing the sum of m+n quaternary ammonium groups and also containing, as main structural unit, the grouping of the formula ##STR2## X.sup..crclbar. is the anion of an acid different from the anion of the formula ##STR3## and m and n denote the entire ion capacity of the copolymer, and the molecular weight of which is about 10.sup.7 to 10.sup.9, a process for the preparation of said resinate, the use thereof as active ingredient of a drug, and pharmaceutical compositions containing it.

REFERENCES:
patent: 3926864 (1975-12-01), Hodgdon, Jr.
patent: 4058491 (1977-11-01), Steckler
patent: 4198395 (1980-04-01), De Simone
patent: 4207399 (1980-06-01), Kumbara
patent: 4380590 (1983-04-01), Chong
Chemical Abstracts-141851d, "Antiinflammatory Action of N-(2,6-dichlorophenyl)-O-aminophenylacetic Acid . . . " 1973, Tsurumi et al.
C.A.-16108w, "Structure-Activity Relationships in a Series of Antiinflammatory N-arylantranilic Acids," Kultenbronn et al., 1983.

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