Ethereal N-terminal aminodiol amino acid derivatives as anti-hyp

Details Ethereal N-terminal aminodiol amino acid derivatives as anti-hyp Ethereal N-terminal aminodiol amino acid derivatives as anti-hyp

1988-07-01

1990-02-13

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548344, A61K 31415, C07D23364

Patent

active

049007467

ABSTRACT:
Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.

REFERENCES:
Umezawa et al., J. Antibiot. (Tokyo), 23:259-262 (1970).
Gross et al., Science, 175, 656 (1971).
Boger, et al., Nature, 303, 81 (1983).
Kokubu et al., Biochim. Biophys. Res. Commun., 118, 929 (1984).
Fehrentz et al., FEBS Lett., 167, 273 (1984).
Hanson et al., Biochm. Biophys. Res. Comm., 132:155-161 (1985), 146:959-963 (1987).
Marshall, Federation Proc., 35: 2494-2501 (1976).
Burton et al., Proc. Natl. Acad. Sci. U.S.A., 77: 5476-5479 (1980).
Suketa et al., Biochemistry, 14: 3188 (1975).
Swales, Pharmac. Ther., 7: 173-201 (1979).
Kokubu et al., Nature, 217: 456-457 (1968).
Matsushita et al., J. Antibiotics, 28: 1016-1018 (1975).
Lazar et al., Biochem. Pharma., 23: 2776-2778 (1974).
Miller et al., Biochem. Pharma., 21: 2941-2944 (1972).
Haber, Clinical Science, 59: 7s-19 s (1980).
Rich et al., J. Org. Chem., 43: 3624 (1978).
Rich et al., J. Med. Chem., 23: 27 (1980).
Haber, Clin. and Exper. Hyper., A5(7&8), 1193 (1983).

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