Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

548344, A61K 31415, C07D23364

Patent

active

049007459

ABSTRACT:
Non-peptidyl compounds characterized generally as poly(aminoalkyl)aminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.

REFERENCES:
Umezawa et al., J. Antibiot. (Tokyo), 23:259-262 (1970).
Gross et al., Science, 175, 656 (1971).
Boger et al., Nature, 303, 81 (1983).
Kokubu et al., Biochem. Biophys. Res. Commun., 118, 929 (1984).
Fehrentz et al., FEBS Lett., 167, 273 (1984).
Hanson et al., Biochm. Biophys. Res. Comm., 132:155-161 (1985), 146:959-963(1987).
Marshall, Federation Proc., 35: 2494-2501 (1976).
Burton et al., Proc. Natl. Acad. Sci. USA, 77: 5476-5479 (1980).
Suketa et al., Biochemistry, 14: 3188 (1975).
Swales, Pharmac. Ther., 7: 173-201 (1979).
Kokubu et al., Nature, 217: 456-457 (1968).
Matsushita et al., J. Antibiotics, 28: 1016-1018 (1975).
Lazar et al., Biochem. Pharma., 23: 2776-2778 (1974).
Miller et al., Biochem. Pharma., 21: 2941-2944 (1972).
Haber, Clinical Science, 59: 7s-19s (1980).
Rich et al., J. Org. Chem., 43: 3624 (1978).
Rich et al. J. Med. Chem., 23: 27 (1980).
Haber, Clin. and Exper. Hyper., A5(7&8), 1193 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1168387

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.