Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-08-05
1990-02-13
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530331, C07K 508, A61K 3702
Patent
active
049007190
ABSTRACT:
Systemic arterial pressure of an animal is decreased by administering directly to the animal an S-nitroso therapeutic compound, and particularly any of the S-nitrosoglutathione, D-(S-nitroso)-3-mercaptomethylpropionyl-L-proline, or S-nitrosothiol serum albumin in a dosage amount effective for a desired decrease and being an amount preferably between about 7 to 10 .mu.g/kg. animal weight/minute.
REFERENCES:
Ignarro, et al., FEBS Letters, 110(2):275-278, 1980.
Craven et al., Biochem. Biophys. Acta, 745: 310-321, 1983.
Saville, Analyst, 83, 670-672, 1958.
Biochemical and Biophysical Research Communications, vol. 94, No. 1, pp. 93-100, Guanylate Cyclase Activation by Nitroprusside and Nitrosoguanidine is Related to Formation of S-Nitrosothiol Intermediates, Louis J. Ignarro et al.
Biochemica et Biophysica Acta, 631(1980) pp. 221-231, "Requirements of Thiols for Activation of Coronary Arterial Guanylate Cyclase by Glyceryl Trinitrate and Sodium Nitrite-Possible Involvement of S-Nitrosothiols", Louis J. Ignarro and Carl A. Gruetter.
The Journal of Pharmacology and Experimental Therapeutics, vol. 218, No. 3, 1981, pp. 739-749, "Mechanism of Vascular Smooth Muscle Relaxation by Organic Nitrates, Nitrites, Nitroprusside and Nitric Oxide; Evidence for the Involvement of S-Nitrosothiols as Active Intermediates", Louis J. Ignarro et al.
The New England Journal of Medicine, Dec. 12, 1985, p. 1548.
"Formation of N-Nitrosoamines from Sodium Nitroprusside and Secondary Amines", Jean Woo Park and Gary E. Means, Biochemical and Biophysical Research Communications, vol. 152, No. 2, pp. 916-920, Apr. 29, 1988, "Reaction of S-Nitrosoglutathione with Sulfhydryl groups in Protein", Jean Woo Park.
Means Gary E.
Park Jeen W.
Foster Frank H.
Perkins Susan M.
Schain Howard E.
The Ohio State University
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