Reagent for detection and measurement of acetaldehyde-protein co

Details Reagent for detection and measurement of acetaldehyde-protein co Reagent for detection and measurement of acetaldehyde-protein co

1986-10-02

1990-02-13

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436544, 436548, 530385, 530402, 530403, 530406, 530387, 424 858, G01N 3355

Patent

active

049006649

ABSTRACT:
A method is provided for detecting and measuring acetaldehyde-protein condensates. An antibody is produced to an antigen, the antibody being cross-reactive with acetaldehyde-protein condensates, these condensates including protein moieties corresponding to or different from the protein moiety of the antigen. Detection and measurement of acetaldehyde-protein condensates may be performed by reacting the antibody with the acetaldehyde-protein condensate to form a complex and measuring the complex.

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Nguyen & Peterson, "The Effect of Acetaldehyde Concs. on the Relative Rates of Formation of Acetaldehyde-Modified Hemoglobins," Proc. Soc. Exp. Biol. Med., vol. 177, pp. 226-233 (1984).
Stevens et al., "Acetaldehyde Adducts with Hemoglobin", J. Clin. Invest., vol. 67, pp. 361-369 (1981).
Israel et al., "Alcohol Abuse: Detection of Acetaldehyde Adducts in Rat Urine Following Administration of Erythrocytes Labelled With Radioactive Acetaldehyde", in `Aldehyde Adducts in Alcoholism` (1985), Alan R. Liss, Inc. Publ., pp. 31-37.
Eshhar, "Monoclonal Antibody Strategy and Techniques", in `Hybridoma Technology in the Biosciences and Medicine`, Ed. T. Springer (1985), pp. 3-41.

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