Process for recycling amine isomer

Details Process for recycling amine isomer Process for recycling amine isomer

1991-03-06

1992-01-21

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564307, 564308, 564425, 564428, C07C20988

Patent

active

050829700

ABSTRACT:
A novel process for converting trans-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine to cis-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine is disclosed. The process involves contacting trans-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine, or a mixture of same with up to about an equal part by weight of the corresponding cis-isomer, with a basic equilibration agent like potassium tert.-butoxide in a reaction-inert polar organic solvent to ultimately afford a cis/trans-mixture wherein the amount of cis-amine present in said mixture achieves a constant value of about 2:1 on a weight-by-weight basis. The aforesaid resultant mixture is useful as an intermediate product that ultimately leads to pure cis-(1S) (4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline), which is a known antidepressant agent.

REFERENCES:
patent: 3506714 (1970-04-01), Hinkley et al.
patent: 4463176 (1984-07-01), Dennis et al.
patent: 4536518 (1985-08-01), Welch, Jr. et al.
patent: 4556676 (1985-12-01), Welch, Jr. et al.

Affiliated with

Also associated with

Rating

Process for recycling amine isomer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for recycling amine isomer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for recycling amine isomer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-116715