Use of diethylcarbamazine to enhance antigen-antibody and antige

Details Use of diethylcarbamazine to enhance antigen-antibody and antige Use of diethylcarbamazine to enhance antigen-antibody and antige

1987-11-13

1990-02-13

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

514589, 436543, 424 858, A61K 3902, A61K 4502, G01N 33531

Patent

active

049005480

ABSTRACT:
This invention relates to the use of diethylcarbamazine (DEC), its analogs, homologs, and pharmaceutically acceptable salts thereof as an antiviral agent. This invention further relates to the use of DEC in in vivo diagnosis to increase antibodies to a particular disease; to the use of DEC in in vitro serologic assays to increase efficacy; and to the use of DEC as a vaccine adjuvant.

REFERENCES:
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patent: 4724232 (1988-02-01), Rideout et al.
patent: 4783446 (1988-11-01), Neushul
patent: 4795739 (1989-01-01), Lifson et al.
Sharpe et al. "Retroviruses and Mouse Embryos: A Rapid Model for Neurovirulence and Transplacental Antiviral Therapy", Science, vol. 230, 26 Jun., 1987, pp. 1671-1674.
Tavares et al. "3'-Azido-3'-deoxythimidine in Feline Leukemia Virus-Infected Cats: A Model for Therapy and Prophylasis of AIDS", Cancer Research 47, 3190-3194, Jun. 15, 1987.
Hardy et al. "FeLV-Induced Feline Acquired Immune Deficiency Syndrome", Prog. Allergy, vol. 37, pp. 353-376, 1986.
Piessens et al. "Effect of Treatment with Diethylcarbamazine on Immune Responses to Filarial Antigens in Patients Infected with Brugia Malayi;"Acta Tropica 38, 227-234 (1981).
Kitchen, "Effect of Diethylcarbamazine on Cats Given Feline Leukaemia Virus Vaccine", Vaccine, vol. 5, Dec., 1987, pp. 266-267.

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