Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dic

Details Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dic Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dic

1990-10-12

1992-01-21

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548539, C07D48704, C07D207337

Patent

active

050829505

ABSTRACT:
5-Aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates of the formula ##STR1## are prepared from 2-aroylpyrroles. Hydrolysis and mono-decarboxylation of these compounds affords ketorolac and related compounds.

REFERENCES:
patent: 4089969 (1978-05-01), Muchowski et al.
patent: 4347185 (1982-08-01), Muchowski et al.
patent: 4347186 (1982-05-01), Muchowski et al.
patent: 4347187 (1982-08-01), Muchowski et al.
patent: 4353829 (1982-10-01), Thurber et al.
patent: 4873340 (1989-10-01), Muchowski et al.
A. Citterio et al., Tet. Lett., 30 (10), 1289-1292 (1989), "Oxidative Deprotonation of Carbonyl Compounds by Fe(III) Salts".
A. Citterio et al., J. Org. Chem., 54, 2713-2718 (1989), "Manganese (III) Acetate Induced Cyclization . . . ".
J. White et al., J. Org. Chem., 42(26), 4248-4251 (1977), "The Vilsmeier-Haack Aroylahon of Pyrrols Reexamined".
C. Gonzalez et al., Can. J. Chem., 61, 1697-1702 (1983), "Protecting Groups for the Pyrrole Nitrogen Atom . . . ".
E. I. Heiba et al., Org. Syn., 61, 22-24, "Substituted .gamma.-Butyrolactones from Carboxylic Acids . . . ".
J. D. McClure, J. Org. Chem., 21, 2365-2368 (1962), "Synthesis of Spiroundecatrienones . . . ".
N. Kornblum et al., J. Am. Chem. Soc., 81, 4113-4114 (1959), "A New and Selective Method of Oxidation . . . ".
L. B. Levy, J. Org. Chem., 54, 253-254 (1989), "Facile Oxidation of Manganese (II) . . . ".
C. Walling, Accts. Chem. Res., 8, 125-131 (1975), "Fenton's Reagent Revisited".
H. C. Brown et al., Angew. Chem. Internat. Ed., 11(8), 692-700 (1972), "Organic Syntheses via Free-Radical Displacement Reactions . . . ".

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